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Immunoassay for the discrimination of free prostate-specific antigen (fPSA) forms with internal cleavages at Lys(₁₄₅) or Lys(₁₄₆) from fPSA without internal cleavages at Lys(₁₄₅) or Lys(₁₄₆).

Abstract:

Total levels of circulating prostate-specific antigen (tPSA) are strongly associated with prostate cancer (PCa) risk and outcome but benign prostate disease is the most frequent cause of a moderately elevated PSA level. Free PSA (fPSA) forms are independently associated with PCa risk and contribute modest diagnostic enhancements above and beyond tPSA alone. We developed an immunoassay for fPSA subfractions containing internal cleavages at Lys(145) or Lys(146) (fPSA-N). The assay was based on ...

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Publisher copy:
10.1016/j.jim.2011.04.006

Authors


Peltola, MT More by this author
Niemelä, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
Journal of immunological methods
Volume:
369
Issue:
1-2
Pages:
74-80
Publication date:
2011-06-05
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
URN:
uuid:2cbb2c5f-0f28-4324-beb3-63fa9c6a4aab
Source identifiers:
365874
Local pid:
pubs:365874

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