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Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation.

Abstract:

Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady-state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositiv...

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Publication status:
Published

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Publisher copy:
10.1084/jem.185.8.1423

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Journal:
The Journal of experimental medicine
Volume:
185
Issue:
8
Pages:
1423-1433
Publication date:
1997-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:2caa9e7a-37af-4dea-92d2-e425c95e9598
Source identifiers:
26123
Local pid:
pubs:26123

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