Journal article
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- Abstract:
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Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41467-024-47399-x
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Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 15
- Issue:
- 1
- Article number:
- 3557
- Publication date:
- 2024-04-26
- Acceptance date:
- 2024-03-26
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
Item Description
- Language:
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English
- Source identifiers:
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1927776
- Deposit date:
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2024-07-20
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