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Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

Abstract:

Dimethyloxalylglycine (DMOG) is an inhibitor of prolyl-4-hydroxylase domain (PHD) enzymes that regulate the stability of hypoxia-inducible factor (HIF). We investigated the effect of DMOG on the outcome after permanent and transient middle cerebral artery occlusion (p/tMCAO) in the rat. Before and after pMCAO, rats were treated with 40 mg/kg, 200 mg/kg DMOG, or vehicle, and with 40 mg/kg or vehicle after tMCAO. Serial magnetic resonance imaging (MRI) was performed to assess infarct evolution ...

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Publication status:
Published

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Publisher copy:
10.1038/jcbfm.2010.60

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
31
Issue:
1
Pages:
132-143
Publication date:
2011-01-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:2c9fae2b-403e-41dc-8cee-c176aa620c2b
Source identifiers:
53400
Local pid:
pubs:53400

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