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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Abstract:

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Ou...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41588-018-0303-9

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Role:
Author
ORCID:
0000-0002-7786-4670
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Role:
Author
ORCID:
0000-0001-7479-0920
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
51
Pages:
51–62
Publication date:
2018-12-21
Acceptance date:
2018-10-31
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:954629
URN:
uri:2c9268c2-5ab6-4f76-bf27-c2fc18804e24
UUID:
uuid:2c9268c2-5ab6-4f76-bf27-c2fc18804e24
Local pid:
pubs:954629

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