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Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia

Abstract:

Background: Maternal circulating levels of anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFlt-1), endoglin (sEng) and placental proteins like activin A and inhibin A are increased before the onset of pre-eclampsia. There is evidence for oxidative stress in pre eclampsia. Recently it was shown that placental oxygen concentration is related to sFlt-1 and inhibin A. In addition it is reported that oxidative stress markers are increased in placental tissue delivered after la...

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Authors


Muttukrishna, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
PLoS ONE
Volume:
4
Issue:
2
Publication date:
2009-02-11
DOI:
EISSN:
1932-6203
URN:
uuid:2c913ee9-1ee9-4c37-9b3a-d366e5ad386a
Source identifiers:
248357
Local pid:
pubs:248357

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