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Journal article

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.

Abstract:

Tumour necrosis factor (TNF) is an important pro-inflammatory cytokine produced in sepsis. Studies examining the association of individual TNF single nucleotide polymorphisms with sepsis have produced conflicting results. This study investigated whether common polymorphisms of the TNF locus and the two receptor genes, TNFRSF1A and TNFRSF1B, influence circulating levels of encoded proteins, and whether individual polymorphisms or extended haplotypes of these genes are associated with susceptib...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gene.6364136

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Journal:
Genes and immunity
Volume:
5
Issue:
8
Pages:
631-640
Publication date:
2004-12-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:2c90b22f-9450-40f7-8abb-82c5e11ff129
Source identifiers:
54386
Local pid:
pubs:54386

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