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Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein.

Abstract:

The Fe65s and X11s are two families of adaptor proteins that bind to the Alzheimer's disease amyloid precursor protein (APP). Although both the X11s and Fe65s bind to similar regions of APP, they have opposing effects on Abeta production and hence may represent novel therapeutic targets. However, there is no evidence that the Fe65s and X11s are present within the same cell type or cell compartment and are thus capable of competing for binding to APP. Here we show that in neurones and transfec...

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Publication status:
Published

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Authors


McLoughlin, DM More by this author
Standen, CL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Miller, CC More by this author
Journal:
Neuroreport
Volume:
11
Issue:
16
Pages:
3607-3610
Publication date:
2000-11-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:2c89d4a5-f57a-463f-a980-f1aab1958564
Source identifiers:
440030
Local pid:
pubs:440030

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