- Abstract:
-
For most associations of common single nucleotide polymorphisms (SNPs) with common diseases, the genetic model of inheritance is unknown. The authors extended and applied a Bayesian meta-analysis approach to data from 19 studies on 17 replicated associations with type 2 diabetes. For 13 SNPs, the data fitted very well to an additive model of inheritance for the diabetes risk allele; for 4 SNPs, the data were consistent with either an additive model or a dominant model; and for 2 SNPs, the dat...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/aje/kwp145
-
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- Journal:
- American journal of epidemiology
- Volume:
- 170
- Issue:
- 5
- Pages:
- 537-545
- Publication date:
- 2009-09-05
- DOI:
- EISSN:
-
1476-6256
- ISSN:
-
0002-9262
- URN:
-
uuid:2c854285-d2bf-41a0-a17a-069ceebb582c
- Source identifiers:
-
21660
- Local pid:
- pubs:21660
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Underlying genetic models of inheritance in established type 2 diabetes associations.
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