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Journal article

Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels.

Abstract:

Arginine (Arg)-based endoplasmic reticulum (ER)-localization signals are involved in the quality control of different heteromultimeric membrane protein complexes. ATP-sensitive potassium (KATP) channels are unique because each subunit in the heterooctamer contains an Arg-based ER-localization signal. We have dissected the inactivation events that override the ER-localization activity of the eight peptide-sorting motifs. Employing a 14-3-3-scavenger construct to lower the availability of 14-3-...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.03196

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Journal of cell science
Volume:
119
Issue:
Pt 20
Pages:
4353-4363
Publication date:
2006-10-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:2c70e559-dd43-42c8-a84f-f892640d4082
Source identifiers:
114731
Local pid:
pubs:114731

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