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Cellular mechanisms of osteoclast formation and lacunar resorption in giant cell granuloma of the jaw.

Abstract:

BACKGROUND: Giant cell granuloma (GCG) is an osteolytic tumour of the jaw which is characterised by the presence of both mononuclear and multinucleated (osteoclast-like) giant cell components. The nature of these component cells and the pathogenesis of the extensive osteolysis associated with this lesion is uncertain. METHODS: Using cell culture techniques and immunohistochemistry, we defined the phenotypic characteristics of the mononuclear and multinucleated cells present in four cases of G...

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Publication status:
Published

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Authors


Itonaga, I More by this author
Hussein, I More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Watt-Smith, S More by this author
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Journal:
Journal of oral pathology and medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Volume:
32
Issue:
4
Pages:
224-231
Publication date:
2003-04-05
DOI:
EISSN:
1600-0714
ISSN:
0904-2512
URN:
uuid:2c703729-7e30-47c1-9d01-9a9d10b65c18
Source identifiers:
103839
Local pid:
pubs:103839

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