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Journal article

p21WAF1/CIP1 and MDM2 expression in non-Hodgkin's lymphoma and their relationship to p53 status: a p53+, MDM2-, p21-immunophenotype associated with missense p53 mutations.

Abstract:

p53 is a tumour suppressor gene which is often found to be inactivated in most types of human cancer. p53 is a transcription factor, the inactivation of which may lead to significant variations in the levels of p53 downstream proteins, such as p21WAF1/CIP1 and MDM2. In view of the significance of p21WAF1/CIP1 and MDM2 as wild-type (wt) p53 targets, this study was undertaken to monitor the varying expression of these proteins in non-Hodgkin's lymphomas (NHLs) in relation to p53 gene status. A ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
Role:
Author
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Journal:
The Journal of pathology
Volume:
181
Issue:
1
Pages:
51-61
Publication date:
1997-01-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:2c64f7b2-a155-4b15-bb05-eb791707aecf
Source identifiers:
486718
Local pid:
pubs:486718

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