Journal article
Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion
- Abstract:
- The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 913.1KB, Terms of use)
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- Publisher copy:
- 10.1093/oxfimm/iqaa004
Authors
- Publisher:
- Oxford University Press
- Journal:
- Oxford Open Immunology More from this journal
- Volume:
- 1
- Issue:
- 1
- Publication date:
- 2020-12-08
- Acceptance date:
- 2020-11-13
- DOI:
- EISSN:
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2633-6960
- Language:
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English
- Keywords:
- Pubs id:
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1150343
- Local pid:
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pubs:1150343
- Deposit date:
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2020-12-21
Terms of use
- Copyright holder:
- Coveney et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 The Author(s). Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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