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Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation.

Abstract:

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase composed of approximately 13 distinct subunits required for progression through meiosis, mitosis, and the G1 phase of the cell cycle. Despite its central role in these processes, information concerning its composition and structure is limited. Here, we determined the structure of yeast APC/C by cryo-electron microscopy (cryo-EM). Docking of tetratricopeptide repeat (TPR)-containing subunits indicates that they likely f...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
20
Issue:
6
Pages:
855-866
Publication date:
2005-12-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:2c397054-a2fa-4d07-a37d-16be76eab180
Source identifiers:
100236
Local pid:
pubs:100236

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