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Role of superoxide dismutase in survival of Leishmania within the macrophage

Abstract:

Intracellular parasitic protozoans of the genus Leishmania depend for their survival on the elaboration of enzymic and other mechanisms for evading toxic free-radical damage inflicted by their phagocytic macrophage host. One such mechanism may involve superoxide dismutase (SOD), which detoxifies reactive superoxide radicals produced by activated macrophages, but the role of this enzyme in parasite survival has not yet been demonstrated. We have cloned a SOD gene from L. tropica and generated ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/BJ20021684

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Portland Press Limited Publisher's website
Journal:
Biochemical Journal Journal website
Volume:
369
Issue:
3
Pages:
447-452
Publication date:
2003-02-01
DOI:
ISSN:
0264-6021
Source identifiers:
505604
Pubs id:
pubs:505604
UUID:
uuid:2c335933-bb33-4f02-b40d-c71de47ad2db
Local pid:
pubs:505604
Deposit date:
2015-01-29

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