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Journal article

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.

Abstract:

The transmembrane phosphatase CD45 regulates both Lck activity and T cell receptor (TCR) signaling. Here we have tested whether the large ectodomain of CD45 has a role in this regulation. A CD45 chimera containing the large ectodomain of CD43 efficiently rescues TCR signaling in CD45-null T cells, whereas CD45 chimeras containing small ectodomains from other phosphatases do not. Both basal Lck activity in unstimulated cells and the TCR-induced increase in tyrosine phosphorylation of the TCR z...

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Publication status:
Published

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Publisher copy:
10.1038/ni877

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Nature immunology
Volume:
4
Issue:
2
Pages:
189-197
Publication date:
2003-02-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
21832

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