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Journal article

Innate immunity in cystic fibrosis lung disease.

Abstract:

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients. The pulmonary immune response in CF is characterized by an early and non-resolving activation of the innate immune system, which is dysregulated at several levels. Here we provide a comprehensive overview of innate immunity in CF lung disease, involving (i) epithelial dysfunction, (ii) pathogen sensing, (iii) leukocyte recruitment, (iv) phagocyte impairment, (v) mechanisms linking innate and adaptive...

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Publication status:
Published

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Publisher copy:
10.1016/j.jcf.2012.07.003

Authors


Bruscia, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
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Journal:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume:
11
Issue:
5
Pages:
363-382
Publication date:
2012-09-05
DOI:
EISSN:
1873-5010
ISSN:
1569-1993
URN:
uuid:2c2336f3-0854-4da0-9453-cdd20cde8944
Source identifiers:
412155
Local pid:
pubs:412155

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