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Induction of cognitive impairment by scopolamine and noncholinergic agents in rhesus monkeys.

Abstract:

In primates, treatment with scopolamine impairs performance of a spatial delayed response task in a way which mimics deficits seen spontaneously in aged primates and demented patients. Despite their efficacy in reversing scopolamine induced disruption, the effects of cholinergic agonists on cognition in aged primates and dements are unimpressive, suggesting that other neurotransmitter systems are also involved in this type of deficit. We have induced a scopolamine-like impairment of spatial d...

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Publication status:
Published

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Authors


Rupniak, NM More by this author
Samson, NA More by this author
Steventon, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Life sciences
Volume:
48
Issue:
9
Pages:
893-899
Publication date:
1991-01-05
DOI:
EISSN:
1879-0631
ISSN:
0024-3205
URN:
uuid:2c1e83da-452b-4a61-9d92-86785fcb54ea
Source identifiers:
22892
Local pid:
pubs:22892

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