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Journal article

Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection.

Abstract:
A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.
Publication status:
Published

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Publisher copy:
10.1128/cvi.05288-11

Authors


Blacksell, SD More by this author
Tanganuchitcharnchai, A More by this author
Jarman, RG More by this author
Gibbons, RV More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
Clinical and vaccine immunology : CVI
Volume:
18
Issue:
10
Pages:
1773-1775
Publication date:
2011-10-05
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
URN:
uuid:2c18ffd7-e69a-4ba2-81f8-5aa81b9be20d
Source identifiers:
172089
Local pid:
pubs:172089

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