- Histone lysine methylation is regulated by Nε-methyltransferases, demethylases, and Nε-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigenetic protein classes with synthetic histone substrates containing l- and d-lysine residues. The results reveal that out of the three classes, Nε-methyl lysine binding proteins are superior in accepting lysines with the d-configuration.
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- Starting Grant to J. M. (ChemEpigen-715691)
- NCI-TA 731.015.202
- Royal Society of Chemistry Publisher's website
- Chemical Communications Journal website
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- Belle et al.
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This is the accepted manuscript version of the article. The final version is available online from Royal Society of Chemistry at: https://doi.org/10.1039/c7cc08028j
Investigating D-lysine stereochemistry for epigenetic methylation, demethylation and recognition
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