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Negative epistasis between α+ thalassaemia and sickle cell trait can explain interpopulation variation in South Asia.

Abstract:

Recent studies in Kenya and Ghana have shown that individuals who inherit two malaria-protective genetic disorders of haemoglobin-α(+) thalassaemia and sickle cell trait-experience a much lower level of malaria protection than those who inherit sickle cell trait alone. We have previously demonstrated that this can limit the frequency of α(+) thalassaemia in a population in which sickle cell is present, which may account for the frequency of α(+) thalassaemia in sub-Saharan Africa not exceedin...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Kanchan, K More by this author
Journal:
Evolution; international journal of organic evolution
Volume:
65
Issue:
12
Pages:
3625-3632
Publication date:
2011-12-05
DOI:
EISSN:
1558-5646
ISSN:
0014-3820
URN:
uuid:2c0f00b5-b27f-4f3c-9248-a7af92cb0410
Source identifiers:
216114
Local pid:
pubs:216114

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