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Journal article

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

Abstract:

Using the dominant control region (DCR) sequences that flank the beta-globin gene locus, we have been able to achieve high-level expression of the human alpha-globin gene in transgenic mice. Expression in fetal liver and blood is copy number dependent and at levels comparable to that of the endogenous mouse alpha-globin genes. Transgenic fetuses with high-copy numbers of the transgene suffer severe anemia and die before birth. Using a construct with both the human alpha- and beta-globin genes...

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Publication status:
Published

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Publisher copy:
10.1101/gad.3.10.1572

Authors


Hanscombe, O More by this author
Luzzatto, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
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Journal:
Genes and development
Volume:
3
Issue:
10
Pages:
1572-1581
Publication date:
1989-10-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:2c08a598-5fb5-4a02-b570-1301b860046c
Source identifiers:
13535
Local pid:
pubs:13535

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