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The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids.

Abstract:

The stereochemical and dynamic properties of the C2' hydroxyl group in several DNA.RNA hybrids have been measured by NMR and compared with the homologous RNA duplex. The C2'-OH NMR signals of the RNA strands were identified, and numerous specific assignments were made. The rate constants for exchange of the hydroxyl protons with water were determined at 5 degrees C, and were found to depend on both the position within a particular sequence and the nature of the duplex. On average, the exchang...

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Publication status:
Published

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Publisher copy:
10.1093/nar/26.13.3104

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Nucleic acids research
Volume:
26
Issue:
13
Pages:
3104-3110
Publication date:
1998-07-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:2c089a7b-dc1a-45e4-a093-ff1ad4166781
Source identifiers:
400266
Local pid:
pubs:400266

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