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Comparison of peptide and superantigen-induced anergy in a peptide-specific polyclonal human T cell line.

Abstract:

T cells recognizing tetanus toxin peptide 'p2' (sequence 830-844) raised in HLA DR6 individuals preferentially express V beta 2 in the TCR. A p2-specific T cell line (60% V beta 2+) was used to compare peptide and superantigen [toxic shock syndrome toxin-1 (TSST-1)]-induced clonal anergy. Many experiments consistently revealed that the degree of 'tolerance' or 'clonal anergy' induced by peptide was greater than with the superantigen TSST-1. These results are of interest in a number of context...

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Publication status:
Published

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Publisher copy:
10.1093/intimm/7.7.1057

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
International immunology
Volume:
7
Issue:
7
Pages:
1057-1063
Publication date:
1995-07-01
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
Source identifiers:
481638

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