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Journal article

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis.

Abstract:

CONTEXT: The adipokine adiponectin has insulin-sensitizing, antiatherogenic, and antiinflammatory properties. Mouse and human adiponectin receptor-1 and -2 have been cloned, both of which are expressed in various tissues and mediate effects of globular and full-length adiponectin. Whether adiponectin affects insulin secretion and beta-cell apoptosis and whether plasma adiponectin is associated with beta-cell function in humans is under investigation. DESIGN AND METHODS: In human islets from m...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2005-0467

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
90
Issue:
12
Pages:
6707-6713
Publication date:
2005-12-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:2bed1e25-9f4f-4186-b1b2-ff20f046597a
Source identifiers:
266143
Local pid:
pubs:266143

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