Journal article
Modeling damage complexity-dependent non-homologous end-joining repair pathway
- Abstract:
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Non-homologous end joining (NHEJ) is the dominant DNA double strand break (DSB) repair pathway and involves several repair proteins such as Ku, DNA-PKcs, and XRCC4. It has been experimentally shown that the choice of NHEJ proteins is determined by the complexity of DSB. In this paper, we built a mathematical model, based on published data, to study how NHEJ depends on the damage complexity. Under an appropriate set of parameters obtained by minimization technique, we can simulate the kinetics...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 854.1KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0085816
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 9
- Issue:
- 2
- Pages:
- ARTN e85816
- Publication date:
- 2014-02-10
- Acceptance date:
- 2013-12-02
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:2bea02ca-a756-4ec8-a9d5-5c62bbe463fd
- Local pid:
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pubs:449131
- Source identifiers:
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449131
- Deposit date:
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2014-05-13
Terms of use
- Copyright date:
- 2014
- Notes:
- This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Attribution (CC BY)
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