Journal article icon

Journal article

The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.

Abstract:

The Ca(2+)-activated K(+) channel KCa3.1 is required for Ca(2+) influx and the subsequent activation of T-cells. We previously showed that nucleoside diphosphate kinase beta (NDPK-B), a mammalian histidine kinase, directly phosphorylates and activates KCa3.1 and is required for the activation of human CD4 T lymphocytes. We now show that the class II phosphatidylinositol 3 kinase C2beta (PI3K-C2beta) is activated by the T-cell receptor (TCR) and functions upstream of NDPK-B to activate KCa3.1 ...

Expand abstract

Actions


Access Document


Publisher copy:
10.1091/mbc.e09-05-0390

Authors


Srivastava, S More by this author
Zhdanova, O More by this author
Vardhana, S More by this author
Expand authors...
Journal:
Molecular biology of the cell
Volume:
20
Issue:
17
Pages:
3783-3791
Publication date:
2009-09-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:2be8f26a-0ea1-4cd5-bce0-0d39b50b75b9
Source identifiers:
426295
Local pid:
pubs:426295

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP