Journal article
Unified single-cell analysis of testis gene regulation and pathology in 5 mouse strains.
- Abstract:
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To fully exploit the potential of single-cell functional genomics in the study of development and disease, robust methods are needed to simplify the analysis of data across samples, time-points and individuals. Here we introduce a model-based factor analysis method, SDA, to analyse a novel 57,600-cell dataset from the testes of wild-type mice and mice with gonadal defects due to disruption of the genes Mlh3, Hormad1, Cul4a or Cnp. By jointly analysing mutant and wild-type cells we decomposed ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 140.7MB, Terms of use)
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- Publisher copy:
- 10.7554/elife.43966
Authors
Funding
Bibliographic Details
- Publisher:
- eLife Sciences Publications
- Journal:
- eLife More from this journal
- Volume:
- 2019
- Issue:
- 8
- Article number:
- e43966
- Publication date:
- 2019-06-25
- Acceptance date:
- 2019-06-17
- DOI:
- ISSN:
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2050-084X
- Pmid:
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31237565
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1026672
- UUID:
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uuid:2be19690-51b3-4672-831d-3bf3747a8162
- Local pid:
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pubs:1026672
- Source identifiers:
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1026672
- Deposit date:
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2019-07-16
Terms of use
- Copyright holder:
- Jung et al
- Copyright date:
- 2019
- Notes:
- © Jung et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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