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Airway response to respiratory syncytial virus has incidental antibacterial effects

Abstract:

RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-10222-z

Authors


Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
10
Article number:
2218
Publication date:
2019-05-17
Acceptance date:
2019-03-26
DOI:
ISSN:
2041-1723
Keywords:
Pubs id:
pubs:987627
UUID:
uuid:2bd390cf-25a6-4522-9a40-8aadeee0c198
Local pid:
pubs:987627
Source identifiers:
987627
Deposit date:
2019-04-06

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