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The Role of Salt Bridges, Charge Density, and Subunit Flexibility in Determining Disassembly Routes of Protein Complexes

Abstract:

Mass spectrometry can be used to characterize multiprotein complexes, defining their subunit stoichiometry and composition following solution disruption and collision-induced dissociation (CID). While CID of protein complexes in the gas phase typically results in the dissociation of unfolded subunits, a second atypical route is possible wherein compact subunits or subcomplexes are ejected without unfolding. Because tertiary structure and subunit interactions may be retained, this is the prefe...

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Publisher copy:
10.1016/j.str.2013.06.004

Authors


Hernández, H More by this author
Robinson, C More by this author
Teichmann, S More by this author
Journal:
Structure
Publication date:
2013
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:2bd34428-6263-4e7c-b13b-5f67c2dce3ec
Source identifiers:
428080
Local pid:
pubs:428080

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