Journal article icon

Journal article

The ER membrane protein complex is a transmembrane domain insertase

Abstract:

Insertion of proteins into membranes is an essential cellular process. The extensive biophysical and topological diversity of membrane proteins necessitates multiple insertion pathways that remain incompletely defined. Here, we found that known membrane insertion pathways fail to effectively engage tail-anchored membrane proteins with moderately hydrophobic transmembrane domains. These proteins are instead shielded in the cytosol by calmodulin. Dynamic release from calmodulin allowed sampling...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1126/science.aao3099

Authors


More by this author
Role:
Author
ORCID:
0000-0003-0757-1255
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
ORCID:
0000-0003-0766-5606
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-0474-1207
More by this author
Role:
Author
ORCID:
0000-0001-8338-852X
More from this funder
Grant:
MC_UP_A022_1007toRSH,
MR/L001209/1toJCC
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
359
Issue:
6374
Pages:
470-473
Publication date:
2017-12-14
Acceptance date:
2017-11-27
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pmid:
29242231
Source identifiers:
813187
Language:
English
Pubs id:
pubs:813187
UUID:
uuid:2bcec143-5734-4b07-acc2-819b2fda3323
Local pid:
pubs:813187
Deposit date:
2018-01-03

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP