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The acute light-induction of sleep is mediated by OPN4-based photoreception.

Abstract:

Sleep is regulated by both homeostatic and circadian mechanisms. The latter, termed 'process c', helps synchronize sleep-wake patterns to the appropriate time of the day. However, in the absence of a circadian clock, overall sleep-wake rhythmicity is preserved and remains synchronized to the external light-dark cycle, indicating that there is an additional, clock-independent photic input to sleep. We found that the direct photic regulation of sleep in mice is predominantly mediated by melanop...

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Publisher copy:
10.1038/nn.2179

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Nature neuroscience
Volume:
11
Issue:
9
Pages:
1068-1073
Publication date:
2008-09-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:2bcd1487-9adb-46ab-9c3f-51e8d51d6e17
Source identifiers:
101389
Local pid:
pubs:101389

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