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Thesis

Study of platelet-mediated clumping adhesion phenotypes in Plasmodium falciparum malaria

Abstract:

Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes (IEs) is a common property of field isolates associated with severe disease (Pain, Ferguson et al. 2001). Platelet receptors CD36 (Pain, Ferguson et al. 2001), P-Selectin (Wassmer, Taylor et al. 2008) and gC1qR (Biswas, Hafiz et al. 2007) mediate clumping. To characterize the molecular specificities of the clumping phenotype, I cloned clumping parasite line IT/C10 by limit...

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Contributors

Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Blood Research Group
Oxford college:
St Cross College
Department:
Medical Sciences Division - Clinical Laboratory Sciences
More from this funder
Funding agency for:
Frank Gekara Onyambu
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:2bc489a9-121e-41ab-8830-1cb07e5b01f2
Local pid:
ora:9771

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