- Abstract:
-
Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes (IEs) is a common property of field isolates associated with severe disease (Pain, Ferguson et al. 2001). Platelet receptors CD36 (Pain, Ferguson et al. 2001), P-Selectin (Wassmer, Taylor et al. 2008) and gC1qR (Biswas, Hafiz et al. 2007) mediate clumping. To characterize the molecular specificities of the clumping phenotype, I cloned clumping parasite line IT/C10 by limit...
Expand abstract - Role:
- Supervisor
- Role:
- Supervisor
- Institution:
- University of Oxford
- Research group:
- Blood Research Group
- Oxford college:
- St Cross College
- Department:
- Medical Sciences Division - Clinical Laboratory Sciences
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:2bc489a9-121e-41ab-8830-1cb07e5b01f2
- Local pid:
- ora:9771
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Frank Onyambu
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available on ORA.
Thesis
Study of platelet-mediated clumping adhesion phenotypes in Plasmodium falciparum malaria
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+ David J Roberts
+ Peter Bull
+ Frank Gekara Onyambu
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