Journal article
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
- Abstract:
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ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient than PARG against poly(ADP-ribose) (PAR) chains in vitro. Here, by using ARH3-deficient cells, we demonstrate that endogenous MARylation persists on chromatin throughout the cell cycle, including mitosis, and is surprisingly well tolerated. Convers...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 5.0MB, Terms of use)
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- Publisher copy:
- 10.1016/j.molcel.2021.04.028
Authors
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Molecular Cell More from this journal
- Volume:
- 81
- Issue:
- 12
- Pages:
- 2640-2655
- Publication date:
- 2021-05-12
- Acceptance date:
- 2021-04-29
- DOI:
- EISSN:
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1097-4164
- ISSN:
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1097-2765
- Pmid:
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34019811
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1178118
- Local pid:
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pubs:1178118
- Deposit date:
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2021-07-14
Terms of use
- Copyright holder:
- Prokhorova et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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