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Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy.

Abstract:

BACKGROUND: Acute HIV infection (AHI) is a critical phase of infection when irreparable damage to the immune system occurs and subjects are very infectious. We studied subjects with AHI prospectively to develop better treatment and public health interventions. METHODS: Cross-sectional screening was employed to detect HIV RNA positive, antibody negative subjects. Date of HIV acquisition was estimated from clinical history and correlated with sequence diversity assessed by single genome amplif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0019617

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Institution:
University of Oxford
Role:
Author
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U.S. National Institutes of Health More from this funder
Bristol Myers Squibb More from this funder
Gilead Sciences, Inc More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
5
Article number:
e19617
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
141946

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