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Flying under the radar: the immunobiology of hepatitis C.

Abstract:

The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent infection in more than two-thirds of those who contract it. Its success is related to its abilities to blunt innate antiviral pathways and to evade adaptive immune responses. These two themes may be related. We propose that HCV takes advantage of the impaired innate response to delay the organization of an effective adaptive immune attack. The tolerogenic liver environment may provide cover, prolonging th...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Annual review of immunology
Volume:
25
Issue:
1
Pages:
71-99
Publication date:
2007
DOI:
EISSN:
1545-3278
ISSN:
0732-0582
URN:
uuid:2bb6a64a-be51-480c-a970-65c7d52c86a6
Source identifiers:
426367
Local pid:
pubs:426367

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