Journal article icon

Journal article

Side-chain conformational disorder in a molten globule: molecular dynamics simulations of the A-state of human alpha-lactalbumin.

Abstract:

Molten globules are compact, partially folded forms of proteins consisting of an ensemble of interconverting conformers with disorder in the side-chain packing across the ensemble. Using insights from experimental data a strategy has been devised to describe this side-chain disorder in a molten globule. Structures of human alpha-lactalbumin have been generated with significantly different side-chain packings to those observed in the native protein by changing all the chi1 torsion angles. Mole...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1006/jmbi.1999.2545

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Role:
Author
Journal:
Journal of molecular biology
Volume:
286
Issue:
5
Pages:
1567-1580
Publication date:
1999-03-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:2bb49921-3970-4757-a944-e5f042b46c44
Source identifiers:
31439
Local pid:
pubs:31439

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP