Molten globules are compact, partially folded forms of proteins consisting of an ensemble of interconverting conformers with disorder in the side-chain packing across the ensemble. Using insights from experimental data a strategy has been devised to describe this side-chain disorder in a molten globule. Structures of human alpha-lactalbumin have been generated with significantly different side-chain packings to those observed in the native protein by changing all the chi1 torsion angles. Mole...Expand abstract
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Side-chain conformational disorder in a molten globule: molecular dynamics simulations of the A-state of human alpha-lactalbumin.
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