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A Comparison of Three Quantitative Methods to Estimate G6PD Activity in the Chittagong Hill Tracts, Bangladesh.

Abstract:

BACKGROUND: Glucose-6-phosphate-dehydrogenase-deficiency (G6PDd) is a major risk factor for primaquine-induced haemolysis. There is a need for improved point-of-care and laboratory-based G6PD diagnostics to unsure safe use of primaquine.

METHODS: G6PD activities of participants in a cross-sectional survey in Bangladesh were assessed using two novel quantitative assays, the modified WST-8 test and the CareStart™ G6PD Biosensor (Access Bio), The results were compared with a gold stand...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0169930

Authors


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Funding agency for:
Ley, B
Grant:
OPRA-OPP1054404
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Funding agency for:
Thriemer, K
Grant:
OPRA-OPP1054404
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Funding agency for:
Price, R
Grant:
091625
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
1
Pages:
e0169930
Publication date:
2017-01-25
Acceptance date:
2016-12-22
DOI:
ISSN:
1932-6203
Source identifiers:
673437
Language:
English
Keywords:
Pubs id:
pubs:673437
UUID:
uuid:2bb41525-dd73-48f2-85cf-f7ff3b4d469e
Local pid:
pubs:673437
Deposit date:
2017-01-29

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