Hailey-Hailey disease: a widespread abnormality of cell adhesion.

Journal article

Suction has been used to investigate cell adhesion in clinically normal skin in Hailey-Hailey disease. We have demonstrated that there is a widespread subclinical abnormality in keratinocyte adhesion in this disease. There may be a synthesis of functionally deficient adhesion junctions, increased breakdown of adhesion junctions or abnormalities in other adhesion proteins in the epidermis in Hailey-Hailey disease. The findings contrast with those in Darier's disease in which abnormal cell adhe...

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Authors: Burge, S; Millard, P; Wojnarowska, F

• Publication status: Published
• Journal: British journal of dermatology
• Volume: 124
• Issue: 4
• Pages: 329-332
• Publication date: 1991-04-01
• DOI: 10.1111/j.1365-2133.1991.tb00592.x
• EISSN: 1365-2133
• ISSN: 0007-0963
• Language: English
• Keywords: Keratinocytes; Suction; Pemphigus; Cell Adhesion; Epidermis; Humans; Adult; Middle Aged; Microscopy, Electron; Male