Journal article icon

Journal article

Planarian flatworms as a new model system for understanding the epigenetic regulation of stem cell pluripotency and differentiation

Abstract:

Planarian flatworms possess pluripotent stem cells (neoblasts) that are able to differentiate into all cell types that constitute the adult body plan. Consequently, planarians possess remarkable regenerative capabilities. Transcriptomic studies have revealed that gene expression is coordinated to maintain neoblast pluripotency, and ensure correct lineage specification during differentiation. But as yet they have not revealed how this regulation of expression is controlled. In this review, we ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1016/j.semcdb.2018.04.007

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More from this funder
Grant:
MR/M000133/1
MR/M000133/1
Publisher:
Elsevier Publisher's website
Journal:
Seminars in Cell and Developmental Biology Journal website
Volume:
87
Pages:
79-94
Publication date:
2018-04-27
Acceptance date:
2018-04-21
DOI:
EISSN:
1096-3634
ISSN:
1084-9521
Pubs id:
pubs:852231
URN:
uri:2ba82420-706e-457f-a3e1-762dcdefc7ff
UUID:
uuid:2ba82420-706e-457f-a3e1-762dcdefc7ff
Local pid:
pubs:852231

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP