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Prolonged activation of virus-specific CD8+T cells after acute B19 infection.

Abstract:

BACKGROUND: Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The phenotype of CD8+ T cells in acute B19 infection has not been studied previously. METHODS AND FINDINGS: The number and phenotype of B19-specific CD8+ T cell responses during and after acute adult infection was studied using HLA-peptide multimeric complexes. Surprisingly, these responses increased in...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.0020343

Authors


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Institution:
University of Oxford
Norbeck, O More by this author
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Institution:
University of Oxford
Jeffery, K More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
2
Issue:
12
Pages:
Article: e343
Publication date:
2005-12-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:2ba0109a-2c06-4d01-977a-6661ee8faa09
Source identifiers:
19264
Local pid:
pubs:19264

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