Parkinson's disease in a dish - Using stem cells as a molecular tool.

Journal article

Parkinson's disease (PD) is the second most common neurodegenerative disease, with a strong genetic component to both the familial and sporadic forms. The cardinal motor symptoms of the disease result from the loss of dopamine (DA) neurons in the midbrain. There is currently no cure for PD and improved methods for modelling the disease are required in order to develop more effective therapeutic interventions. Patient-derived induced pluripotent stem cells (iPSCs) carry the genetic background ...

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Authors: Badger, J; Cordero-Llana, O; Hartfield, E; Wade-Martins, R

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 76 Pt A
• Issue: PART A
• Pages: 88-96
• Publication date: 2014-01-01
• DOI: 10.1016/j.neuropharm.2013.08.035
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Dopaminergic Neurons; Protein-Serine-Threonine Kinases; Cell Differentiation; alpha-Synuclein; Ubiquitin-Protein Ligases; Glucosylceramidase; Models, Genetic; Mutation; Humans; Parkinson Disease; Protein Kinases; Induced Pluripotent Stem Cells