Paraneoplastic chronic demyelinating neuropathy and Lambert-Eaton myasthenic syndrome associated with multiple anti-neural antibodies and small-cell lung cancer.

Journal article

Lambert-Eaton myasthenic syndrome (LEMS) developed in a patient with presumed chronic inflammatory demyelinating polyneuropathy (CIDP) and negative chest CT. Since antibodies against both Hu and voltage-gated calcium channel (VGCC) were detected, repeated chest CT was performed, which eventually showed a pulmonary mass lesion. Biopsy revealed small cell lung cancer (SCLC) indicating the importance of repeated chest CT in LEMS even when an existing autoimmune-like disease and negative CT may suggest an autoimmune origin. This is the first report of paraneoplastic CIDP and LEMS associated with anti-Hu, anti-VGCC and SCLC.

Authors: Rozsa, C; Vincent, A; Aranyi, Z; Kovacs, G; Komoly, S

• Publication status: Published
• Journal: Ideggyogyaszati szemle
• Volume: 61
• Issue: 9-10
• Pages: 325-328
• Publication date: 2008-09-01
• ISSN: 0019-1442
• Language: English
• Keywords: Female; Lambert-Eaton Myasthenic Syndrome; Humans; Demyelinating Diseases; Lung Neoplasms; Paraneoplastic Syndromes, Nervous System; Carcinoma, Small Cell; Hu Paraneoplastic Encephalomyelitis Antigens; Middle Aged