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Diffusivity and distribution of vinblastine in three-dimensional tumour tissue: experimental and mathematical modelling.

Abstract:

The distribution of chemotherapeutics in solid tumours is poorly understood and the contribution it makes to treatment failure is unknown. Novel approaches are required to understand how the three-dimensional organisation of cancer cells in solid tumours affects drug availability. Since convective drug transport is limited by increased interstitial pressure in poorly vascularised cancers, the aim of this study was to measure the diffusive hindrance exerted by solid tumour tissue. Multicell la...

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Publication status:
Published

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Publisher copy:
10.1016/j.ejca.2006.05.020

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
European journal of cancer (Oxford, England : 1990)
Volume:
42
Issue:
14
Pages:
2404-2413
Publication date:
2006-09-05
DOI:
EISSN:
1879-0852
ISSN:
0959-8049
URN:
uuid:2b848539-76bb-4853-a7e5-a16cdd25e912
Source identifiers:
10178
Local pid:
pubs:10178

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