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Journal article

Complement factor I in health and disease.

Abstract:

Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to degrade activated complement proteins C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1 or CD46. Complete deficiency of FI, which is synthesized mainly in the liver is rare and leads to complement consumption resulting in recurrent severe infections, glomerulonephritis or autoimmune diseases. Incomplete FI deficiency is in turn associated with atyp...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Molecular immunology
Volume:
48
Issue:
14
Pages:
1611-1620
Publication date:
2011-08-05
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
URN:
uuid:2b7c377d-ec22-44b8-984e-1c80e730331c
Source identifiers:
175454
Local pid:
pubs:175454

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