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Drosophila Squid/hnRNP helps Dynein switch from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies.

Abstract:

In Drosophila oocytes, dorso-anterior transport of gurken mRNA requires both the Dynein motor and the heterogeneous nuclear ribonucleoprotein (hnRNP) Squid. We show that gurken transcripts are transported directly on microtubules by Dynein in nonmembranous electron-dense transport particles that also contain Squid and the transport cofactors Egalitarian and Bicaudal-D. At its destination, gurken mRNA is statically anchored by Dynein within large electron-dense cytoplasmic structures known as ...

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Publication status:
Published

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Authors


Delanoue, R More by this author
Herpers, B More by this author
Soetaert, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Rabouille, C More by this author
Journal:
Developmental cell
Volume:
13
Issue:
4
Pages:
523-538
Publication date:
2007-10-05
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:2b724bae-972d-4059-b914-4529af64dbe9
Source identifiers:
100872
Local pid:
pubs:100872

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