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Molecular radiotherapy using cleavable radioimmunoconjugates that target eGFR and γH2AX

Abstract:

Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation ofDNA double-strand breaks (DSB). Delivery of therapeutic radionuclides to DNA DSB sites can amplify this DNA damage, for additional therapeutic gain. Herein,wereport on two radiopharmaceuticals, radiolabeled with the Auger electron emitter 111In, with dual specificity for both the intranuclear, DNA damage repair signaling protein γH2AX and the EGF receptor (EGFR). The EGFR ligand EGF was conju...

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Publisher copy:
10.1158/1535-7163

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Vallis, KA More by this author
Vallis, KA More by this author
Journal:
Molecular Cancer Therapeutics
Volume:
12
Issue:
11
Pages:
2472-2482
Publication date:
2013-11-01
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
URN:
uuid:2b6d5495-efff-4480-8c59-ebda7dc357f0
Source identifiers:
441009
Local pid:
pubs:441009

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