Journal article
Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes
- Abstract:
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Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants. Beta-lactam antibiotic resistance in Streptococcus pneumoniae arises readily as the bacteria can quickly incorporate DNA fragments encompassing variants that make the transformed strains resistant. However, the causative mutations themselves are embedded within larger recombined blocks, and ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.1MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pgen.1004547
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Genetics More from this journal
- Volume:
- 10
- Issue:
- 8
- Pages:
- ARTN e1004547
- Publication date:
- 2014-08-07
- Acceptance date:
- 2014-06-16
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:479270
- UUID:
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uuid:2b5a14c8-2d56-49da-b1a1-8c3ac13c9bbc
- Local pid:
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pubs:479270
- Source identifiers:
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479270
- Deposit date:
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2014-08-16
Terms of use
- Copyright holder:
- Chewapreecha et al
- Copyright date:
- 2014
- Notes:
- Copyright: © 2014 Chewapreecha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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