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Is immune senescence reversible?

Abstract:

Many genes have been shown to be involved in the decline in immune function of the elderly. However, normal numbers of myeloid and lymphoid colonies can be grown from elderly bone marrow under optimal conditions and some thymic function is preserved well into adult life. It may also be possible to reverse partially declining thymic function by IL-7 treatment. Peripheral B and T cells show evidence of dysregulation with production of large clones, changes in subset distribution and altered sig...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Vaccine
Volume:
18
Issue:
16
Pages:
1721-1724
Publication date:
2000-02-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:2b598c58-4949-4136-b78e-e46563febaf9
Source identifiers:
31629
Local pid:
pubs:31629

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