Catalytic intramolecular ketone hydroacylation: enantioselective synthesis of phthalides.

Journal article

Controlling carbonyl groups: Identification of the correct ligand/counterion combination was essential to allow the efficient and selective rhodium-catalyzed conversion of a series of ketobenzaldehydes into the corresponding phthalides using the title reaction (see scheme; cod=cycloocta-l,5-diene). © 2010 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim.

Authors: Willis, M

• Publication status: Published
• Journal: Angewandte Chemie (International ed. in English)
• Volume: 49
• Issue: 35
• Pages: 6026-6027
• Publication date: 2010-08-01
• DOI: 10.1002/anie.201000159
• EISSN: 1521-3773
• ISSN: 1433-7851
• Language: English
• Keywords: hydroacylation; lactones; asymmetric catalysis; rhodium; ketones